For rare earth containing apatite, the combined process of beneficiation and metallurgy was used to extract rare earth in the form of rare earth oxide and recover phosphorus in the form of nitrogen and phosphate fertilizer. For the refractory low-grade tantalum, niobium, tungsten, molybdenum, tin and bismuth ores, the efficient separation and deep enrichment of the minerals are carried out by using multi-field synergistic method.